pAkt is a marker for poor prognosis in breast cancer 1 High throughput time-resolved-FRET reveals Akt/PKB activation as a poor prognosic marker in breast cancer
نویسندگان
چکیده
1 Cell Biophysics, 3 Protein Phosphorylation Experimental Histopathology Laboratories, Cancer Research UK, London Research Institute, London, UK. 2 Centre Emotion, Hôpital de la Pitié Salpetriere, Paris, France 5 Stanford University School of Medicine, Stanford, USA 6 Cancer Division King’s College London, London, UK 7 Cell Biophysics Laboratory, Unidad de Biofísica (CSIC-UPV/EHU), Sarriena s/n, 48940 Leioa, Spain. Ikerbasque, Basque Foundation for Science
منابع مشابه
Integrated Systems and Technologies High-Throughput Time-Resolved FRET Reveals Akt/PKB Activation as a Poor Prognostic Marker in Breast Cancer
Dysregulation of the Akt/PKB pathway has been associated with poor prognosis in several human carcinomas. Current approaches to assess Akt activation rely on intensity-basedmethods, which are limited by the subjectivity of manual scoring and poor specificity. Here, we report the development of a novel assay using amplified, timeresolved F€ orster resonance energy transfer (FRET), which is highl...
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تاریخ انتشار 2014